Neuro Research Notes
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Intracellular Loop in the Brain Isoforms of Anoctamin 2 Channels Regulates Calcium-dependent Activation
Dongsu Lee, Hocheol Lim, Jungryun Lee, Go Eun Ha, Kyoung Tai No, Eunji Cheong (Yonsei University) Experimental Neurobiology (2023) Abstract: Examines two brain splice variants (isoforms) of the calcium-activated chloride channel ANO2. Isoform expression differs across brain regions → functional specialization. Electrophysiology and computational modeling were used to link structure to channel behavior. Goal: explain how structural differences affect calcium-dependent…
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Structure-based drug discovery of a corticotropin-releasing hormone receptor 1 antagonist using an X-ray free-electron laser
Hoyoung Kim, Taehyun Lim, Go Eun Ha, Jee-Young Lee, Jun-Woo Kim, Nienping Chang, Si Hyun Kim, Ki Hun Kim, Jaeick Lee, Yongju Cho, Byeong Wook Kim, Alva Abrahamsson, Sung Hwan Kim, Hyo-Ji Kim, Sehan Park, Sang Jae Lee, Jaehyun Park, B. Moon Kim, Hyun-Soo Cho & Eunji Cheong (Yonsei University) Experimental and Molecular Medicine (2023)…
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Suffruticosol B from Paeonia lactiflora Ameliorates Alzheimer’s Disease Pathology by Inhibiting MAO-B Activity
Jae-Jun Heo, Young-Eun Han, Min Soo Kim, Eunji Cheong, Chun Whan Choi, Soo-Jin Oh (Yonsei University) Phytotherapy Research (2025) Suffruticosol B: specific chemical compounds natural products found in the medicinal plant Paeonia suffruticosa (tree peony), and known for potential health benefits. MAO-B Activity: function of Monoamine Oxidase B, an enzyme that breaks down neurotransmitters like dopamine and plays a role in oxidative stress,…
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Digital Assessment of Cognitive-Affective Biases Related to Mental Health
Sang-Eon Park, Jisu Chung, Jeonghyun Lee, Minwoo JB Kim, Jinhee Kim, Hong Jin Jeon, Hyungsook Kim, Choongwan Woo, Hackjin Kim, Sang Ah Lee (Seoul National University) PLOS Digital Health (2024) Abstract: The researchers created digital tasks to measure how people’s thinking and feelings may be biased, across ages and in clinical groups. They provided a…
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Neurocognitive basis of navigation in children
Sang-Ah Lee Department of Brain and Cognitive Sciences, Seoul National University (2024) Abstract: Studying navigation in children is hard because young kids can’t move around independently. Comparing child studies with animal research helps explain why children’s spatial memory differs from adults’. Some uniquely human spatial abilities need to be studied alongside brain development. Findings: Children…
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Scene construction processes in the anterior hippocampus during temporal episodic memory retrieval
Maria Jieun Hwang, Sang-Ah Lee (Seoul National University) Hippocampus (2024) Abstract: The study tests whether the anterior hippocampus builds full-scene representations when only partial cues are given. Participants saw sequences of photos (objects + background), then at retrieval judged temporal order using either full scenes, only objects, or only backgrounds. Using fMRI, the researchers looked…
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Neuroscience Course (UChicago)
Course Name: Understanding the Brain: The Neurobiology of Everyday Life This course took me about 3-5 months to finish since I was also prepping for school and SAT. Through this course, I learned different topics in neuroscience. It’s mostly basic knowledge, but it had application to our lives. Some of the topics that we covered…
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